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May 10, 2026Communications Medicine2 citationsOpen Access

Diagnosing and defining MASLD in people living with chronic hepatitis B

EMEmily MartynAAAlejandro Arenas-PintoRGRichard Gilson

Key Points

  • The aim is to understand the relationship between chronic hepatitis B and metabolic dysfunction-associated steatotic liver disease.
  • Reviewed diagnostic tools for identifying MASLD in chronic hepatitis B patients.
  • Analyzed data on liver inflammation and fibrosis linked to MASLD.
  • Advocated for consensus on diagnostic standards and better health access.
  • Identified inconsistencies in the application of diagnostic tools across global populations.
  • Recommended evidence-based monitoring practices to improve patient outcomes.
  • Highlighted the need for enhanced access to interventions to reduce health inequity.

Abstract

Abstract Chronic hepatitis B (CHB) infection and metabolic dysfunction-associated steatotic liver disease (MASLD) are important contributors to the growing worldwide burden of liver disease. There is limited understanding regarding the interaction between CHB and MASLD. This is a consequence of the changing terminology for liver disease, inconsistent application of diagnostic tools, and poor understanding of global populations. In this review, we collate data on the use of diagnostic tests for identifying MASLD and associated liver inflammation or fibrosis in people living with CHB. We advocate for improved consensus on diagnosis, evidence-based monitoring and risk stratification, enhanced access to interventions and reduced health inequity.

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Cite This Study

Martyn et al. (2026) studied this question.

synapsesocial.com/papers/6a002126c8f74e3340f9bfb6https://doi.org/10.1038/s43856-026-01383-2
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