Why the study?
What are the risk factors, angiographic patterns, and mortality outcomes of ventricular septal defect complicating acute myocardial infarction in patients receiving thrombolytic therapy?
Population
41,021 patients with acute myocardial infarction treated with thrombolysis in the GUSTO-I trial
Comparison
Development of ventricular septal defect (VSD) vs No development of VSD
Design
Cohort
Follow-up
1 year
Authors
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Post-MI VSD remains associated with high mortality; extends prior observations but leaves open optimal management in contemporary practice.
What are the risk factors, angiographic patterns, and mortality outcomes of ventricular septal defect complicating acute myocardial infarction in patients receiving thrombolytic therapy?
In the thrombolytic era, VSD complicating acute myocardial infarction is rare (0.2%) but carries an extremely high 30-day mortality (73.8%), though surgical repair yields better outcomes than medical therapy.
Crenshaw et al. (2000) studied this question.