Why the study?
Age-related LV diastolic and vascular dysfunction leading to HFpEF lacks preventive strategies, prompting investigation into whether dietary alpha linolenic acid prevents these impairments.
Does long-term dietary alpha linolenic acid (ALA) prevent LV diastolic dysfunction and vascular aging in wild-type C57BL/6 J mice?
Population
Wild-type C57BL/6 J mice starting at 6 months of age
Comparison
Chow diet vs ALA diet
Design
Preclinical murine study
Follow-up
12 months
Key result
Long-term dietary alpha linolenic acid supplementation prevented age-related left ventricular diastolic dysfunction, impaired vasorelaxation, cardiac fibrosis, and arterial stiffening in aged mice.
Authors
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Does not support clinical use of dietary ALA to prevent diastolic dysfunction; leaves open translation of murine benefits to human aging.
Does long-term dietary alpha linolenic acid (ALA) prevent LV diastolic dysfunction and vascular aging in wild-type C57BL/6 J mice?
Long-term dietary supplementation with alpha linolenic acid prevents age-related left ventricular diastolic dysfunction and vascular aging in a murine model.
Saravi et al. (2023) studied aging-related cardiac diastolic and vascular dysfunction. dietary alpha linolenic acid (ALA) vs. chow diet was evaluated on LV diastolic dysfunction and vascular aging. Long-term dietary alpha linolenic acid supplementation prevented age-related left ventricular diastolic dysfunction, impaired vasorelaxation, cardiac fibrosis, and arterial stiffening in aged mice.