ABSTRACT Amyloidosis is a heterogeneous group of disorders caused by extracellular deposition of misfolded proteins, leading to organ dysfunction. Gastrointestinal involvement is common but often under-recognized, and presentations vary widely depending on the amyloid subtype. We present a case of a 68-year-old man with chronic gastrointestinal symptoms, ultimately diagnosed with AL amyloidosis associated with lymphoplasmacytic lymphoma. Management included chemotherapy and supportive measures for the gastrointestinal symptoms. This case highlights the importance of considering amyloidosis in patients with chronic gastrointestinal symptoms, particularly in the setting of plasma cell dyscrasias.
Fansa et al. (2026) studied this question.