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September 10, 2025Sexual Health0 citations

Metabolic Safety of Hormonal Treatment in Transgender Women: A Review

Metabolic safety of gender-affirming hormonal treatment in transgender females

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Authors

CMCharalampos MilionisKBKonstantina BaroutiVPVassiliki Papadopoulou

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Overview

Observational analysis evaluates metabolic parameters in transgender women receiving gender-affirming therapy, indicating safety and importance of hormone levels.

Key Points

  • Transgender women receiving hormonal treatment showed stable estradiol and testosterone levels, indicating effective therapy.
  • After 18 months, an increase in blood triglycerides was observed, while hemoglobin and hematocrit levels decreased significantly.
  • Participants did not experience severe hypertriglyceridemia or anemia, suggesting manageable metabolic safety.
  • Findings underscore the necessity of maintaining hormone levels within therapeutic targets during gender-affirming treatment.

Cite This Study

Milionis et al. (2025) studied this question.

synapsesocial.com/papers/68c1c31b54b1d3bfb60f089fhttps://doi.org/10.1071/sh25113
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