Supplementary Figure 4 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Puntos clave

• SPP1+ tumor-associated macrophages drive CD8 T-cell dysfunction, leading to immunotherapy resistance.
• Flow cytometry results reveal specific gating strategies for identifying SPP1+ TAMs in renal cell carcinoma.
• The study focuses on the immunological landscape of clear-cell renal cell carcinoma and its resistance mechanisms.
• Identifying TAMs may enhance understanding of treatment responses and inform future therapeutic strategies.

Resumen