Mp56-10 Long-Term Oncological and Functional Outcomes Following Robotic Partial and Radical Nephrectomy in Patients Who Survived Beyond Five Years

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy IV (MP56)1 May 2024MP56-10 LONG-TERM ONCOLOGICAL AND FUNCTIONAL OUTCOMES FOLLOWING ROBOTIC PARTIAL AND RADICAL NEPHRECTOMY IN PATIENTS WHO SURVIVED BEYOND FIVE YEARS Nicolas A. Soputro, Ethan L. Ferguson, Roxana Ramos-Carpinteyro, Jaya S. Chavali, Adriana M. Pedraza, Carter Mikesell, Khaleed Fareed, Ryan Berglund, Robert J. Stein, Georges P. Haber, Steven C. Campbell, Christopher J. Weight, and Jihad Kaouk Nicolas A. SoputroNicolas A. Soputro , Ethan L. FergusonEthan L. Ferguson , Roxana Ramos-CarpinteyroRoxana Ramos-Carpinteyro , Jaya S. ChavaliJaya S. Chavali , Adriana M. PedrazaAdriana M. Pedraza , Carter MikesellCarter Mikesell , Khaleed FareedKhaleed Fareed , Ryan BerglundRyan Berglund , Robert J. SteinRobert J. Stein , Georges P. HaberGeorges P. Haber , Steven C. CampbellSteven C. Campbell , Christopher J. WeightChristopher J. Weight , and Jihad KaoukJihad Kaouk View All Author Informationhttps://doi.org/10.1097/01.JU.0001008940.44711.d4.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Partial nephrectomy (PN) has long been established as the preferred treatment for small and localized renal masses, with a strong emphasis towards the balance between renal function preservation and satisfactory oncological outcomes. With the increasing utilization of robotic surgery for both PN and radical nephrectomy (RN), this study sought to evaluate the long-term functional and oncological trajectories in patients who survived beyond five years following robotic PN and RN. METHODS: A retrospective review was performed on the prospectively maintained, IRB-approved database to identify 1816 patients who underwent primary robotic PN and RN between 2006 and 2018. Patients with a long-term follow-up of at least five years were included. Exclusion criteria included those with known genetic mutations and whose procedures were performed for benign indications. Statistical analysis was performed using the R Project for Statistical Computing. RESULTS: A total of 769 PN and 142 RN cases were included. At a median follow-up duration of nearly 100 months, the RCC-specific mortality rates were similar between the groups at 1.1% and without any significant differences in terms of the local recurrence and metastatic-free survival rates. We did not identify any patient with pT4 disease in our RN cohort. In terms of functional outcomes, the 5- and 10-year chronic kidney disease (CKD) progression-free survival rates were 74.5% and 65.9% following PN and 53% and 46.4% after RN, respectively (p<0.05). Older age, higher BMI, and longer ischemia time were identified as potential predictors for CKD progression following PN. CONCLUSIONS: Compared to RN, PN conferred a better long-term CKD progression-free survival whilst maintaining similarly satisfactory oncological outcomes. Despite clinically significant CKD upstaging being evident in some cases, most of our patients demonstrated relatively stable and good preservation of renal function throughout the long follow-up duration of up to 15 years. Download PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e929 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Nicolas A. Soputro More articles by this author Ethan L. Ferguson More articles by this author Roxana Ramos-Carpinteyro More articles by this author Jaya S. Chavali More articles by this author Adriana M. Pedraza More articles by this author Carter Mikesell More articles by this author Khaleed Fareed More articles by this author Ryan Berglund More articles by this author Robert J. Stein More articles by this author Georges P. Haber More articles by this author Steven C. Campbell More articles by this author Christopher J. Weight More articles by this author Jihad Kaouk More articles by this author Expand All Advertisement PDF downloadLoading ...