Abstract 1947 Exploring the Interplay of Social- Economic, and Racial Disparities Stress and Their Impact on Breast Cancer, with a Focus on Triple Negative Breast Cancer and Hormonal Imbalance-Induced Early Immune Cell Aging

Breast cancer remains a complex and multifaceted health challenge, with emerging evidence suggesting a profound interconnection between social, economic, and racial disparities, chronic stress, and the development of breast cancer (BC) notably in Triple negative breast cancer (TNBC). TNBC is prevalent in African American, Hispanic. This study investigates the intricate pathways through which socio-economic status, and the stress from the racial inequities contribute to the onset and progression of BC , with a specific focus on the hormonal imbalances induced premature aging of immune cells. Socioeconomic factors, including income disparities and limited access to healthcare resources, are explored as potential stressors that trigger chronic psychological and physiological stress. These stressors, in turn, are linked to disruptions in hormonal balance, particularly the dysregulation of cortisol and sex hormones. Racial and ethnic disparities are analyzed as crucial components of this complex interplay, with a focus on understanding how systemic inequalities contribute to chronic stress experienced by marginalized populations. For Black women and the Hispanic women have constant exposure to race-related stresses that causes hormonal imbalances leading to pre-mature immune aging. This study further develops into the specific impact of chronic stress-induced hormonal imbalances on the immune system leading to premature immune aging, revealing a potential mechanism by which stress-induced hormonal imbalances accelerates the aging of immune cells thereby delayed immune response leading poor breast cancer outcome. We will test a novel hypothesis that declining of the immune fitness in the Black and Hispanic Women leads to transcriptional heterogeneity in the immune cells leading to increase in low-grade inflammation, changes in the composition of microbiome and the mediators of this systemic inflammation such as pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor (TNF-alpha) and changes in the female sex hormone estrogen and progesterone. For this our study will analyze the check the race -specific immune signatures through multi parametric immunoprofiling due to the racial disparities in a small cohort of sample and will corelate the data with the change in the level of female sex hormone. Finally, all data were correlated with patient outcome. The results obtained from this study will identify therapeutic strategies for improving anti-tumor immunity and can be used as a part of clinical risk assessment. Discovery Foundation Advancing the Discovery to Market.