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January 25, 2026Nutrients0 citationsOpen Access

Associations Between Serum 25-Hydroxyvitamin D Levels and Metabolic Syndrome Among Korean Adolescents: Based on the Korea National Health and Nutrition Examination Survey in 2022–2023

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MCM ChoAjou University HospitalYSYoung Suk ShimHLHae Sang LeeAjou University Hospital

Key Points

  • This study aims to examine the relationship between serum 25-hydroxyvitamin D levels and metabolic syndrome among Korean adolescents.
  • Analyzed data from the 2022–2023 Korea National Health and Nutrition Examination Survey
  • Included adolescents aged 10–18 years with serum 25-hydroxyvitamin D measurements
  • Categorized vitamin D levels into quartiles and performed weighted analyses
  • Examined associations using complex-sample general linear models
  • Estimated odds ratios for metabolic syndrome components using logistic regression models
  • 62.4% of adolescents were found to be vitamin D deficient (<20 ng/mL)
  • Higher vitamin D quartiles correlated with lower obesity-related indices like BMI and waist circumference
  • No significant associations were found for blood pressure, fasting glucose, or lipid parameters
  • Vitamin D deficiency was linked to higher odds of waist circumference ≥90th percentile (OR 2.59)
  • Metabolic syndrome did not show significant association with vitamin D deficiency

Abstract

Background/Objectives: Vitamin D is a nutrient involved not only in bone metabolism but also in metabolic functions, and deficiency is common during adolescence. This study aimed to describe the distribution of serum 25-hydroxyvitamin D levels among Korean adolescents and to examine their associations with metabolic syndrome and its individual components. Methods: We analyzed data from the 2022–2023 Korea National Health and Nutrition Examination Survey. Adolescents aged 10–18 years with serum 25-hydroxyvitamin D measurements were included (unweighted N = 880). Weighted analyses were performed by categorizing serum 25-hydroxyvitamin D levels into quartiles. Associations between vitamin D quartiles and anthropometric and metabolic parameters were examined using complex-sample general linear models, and odds ratios for metabolic syndrome and its individual components according to vitamin D deficiency were estimated using complex-sample logistic regression models. Results: Weighted prevalence of vitamin D deficiency ( 0.5 (OR 2.63), and BMI ≥ 95th percentile (OR 1.89), while metabolic syndrome was not significant. Conclusions: Vitamin D appears to play an important role in metabolic health in adolescents and was particularly associated with general and central obesity.

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Cite This Study

Cho et al. (2026) studied this question.

synapsesocial.com/papers/6975b38dfeba4585c2d6efa0https://doi.org/10.3390/nu18020360
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