Global whole-genome–based genomic insights into Mycobacterium tuberculosis: Clonal dominance, sequence-type structure, and antimicrobial resistance-virulence landscapes
In silico analysis reveals clonal dominance and resistance patterns in Mycobacterium tuberculosis, indicating the need for careful genomic interpretation.
Key Points
To analyze the global genomic distribution and resistance characteristics of Mycobacterium tuberculosis.
Conducted a large-scale in silico analysis of whole-genome sequences
Examined sequence-type distribution and geographic structuring
Assessed resistance-associated gene prevalence from public datasets
Identified a skewed sequence-type distribution of M. tuberculosis worldwide
Observed geographic structuring in the distribution patterns
Found widespread presence of chromosomal resistance-associated genes