What does this research mean for the field?

The study introduces novel eco-friendly spectrophotometric methods for the simultaneous quantification of amlodipine, telmisartan, and indapamide in pharmaceutical formulations. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to develop accurate spectrophotometric methods for quantifying a triple antihypertensive drug combination in a sustainable manner.

March 2, 2026Results in ChemistryOpen Access

Merging green chemistry with spectrophotometry: Univariate vs. multivariate assessment of a novel triple antihypertensive combination, amlodipine, telmisartan, and indapamide

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Authors

AKAhmed K. Kammoun AKAlaa Khedr MFMichael Gamal Fawzy

Discussion

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Overview

Novel spectrophotometric methods determine antihypertensive drugs' concentrations, suggesting eco-friendly solutions for complex formulations.

Key Points

The aim is to develop accurate spectrophotometric methods for quantifying a triple antihypertensive drug combination in a sustainable manner.
Developed two spectrophotometric platforms: Fourier self-deconvolution and Third derivative.
Constructed two chemometric models: Partial Least Squares and Principal Component Regression.
Evaluated methods' greenness using multiple assessment tools, including MoGAPI and spider diagrams.
Validated methods according to ICH guidelines and ensured accuracy with standard addition techniques.
Successfully quantified amlodipine, telmisartan, and indapamide in combined formulations.
Models showed high predictive accuracy with RMSEP values ranging from 0.0749 to 0.4535.
No significant difference in accuracy and precision compared to traditional HPLC methods at p = 0.05.
Methods reduced environmental impact by eliminating hazardous solvents, supporting sustainable analytical practices.

Cite This Study

Kammoun et al. (2026) studied this question.

synapsesocial.com/papers/69a52d9af1e85e5c73bf08b5 https://doi.org/10.1016/j.rechem.2026.103192

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March 2, 2026Results in ChemistryOpen Access

Merging green chemistry with spectrophotometry: Univariate vs. multivariate assessment of a novel triple antihypertensive combination, amlodipine, telmisartan, and indapamide

View Full Paper

Ask AI

Bookmark

Authors

AKAhmed K. Kammoun AKAlaa Khedr MFMichael Gamal Fawzy

Discussion

Member takes

Overview

Novel spectrophotometric methods determine antihypertensive drugs' concentrations, suggesting eco-friendly solutions for complex formulations.

Key Points

The aim is to develop accurate spectrophotometric methods for quantifying a triple antihypertensive drug combination in a sustainable manner.
Developed two spectrophotometric platforms: Fourier self-deconvolution and Third derivative.
Constructed two chemometric models: Partial Least Squares and Principal Component Regression.
Evaluated methods' greenness using multiple assessment tools, including MoGAPI and spider diagrams.
Validated methods according to ICH guidelines and ensured accuracy with standard addition techniques.
Successfully quantified amlodipine, telmisartan, and indapamide in combined formulations.
Models showed high predictive accuracy with RMSEP values ranging from 0.0749 to 0.4535.
No significant difference in accuracy and precision compared to traditional HPLC methods at p = 0.05.
Methods reduced environmental impact by eliminating hazardous solvents, supporting sustainable analytical practices.

Cite This Study

Kammoun et al. (2026) studied this question.

synapsesocial.com/papers/69a52d9af1e85e5c73bf08b5 https://doi.org/10.1016/j.rechem.2026.103192

View Full Paper

Ask AI

Bookmark