Can patient-specific lumped-parameter models quantify vessel-specific remodeling and predict right ventricular function in pulmonary hypertension?
Computational lumped-parameter models show potential as noninvasive, clinically feasible tools for assessing pulmonary vascular remodeling and right ventricular function in pulmonary hypertension.
Our results demonstrate that lumped-parameter models can be calibrated to clinical data to quantify vessel-specific remodeling and simulate RV pressure-volume dynamics to provide useful information for distinguishing among different PH phenotypes. This underscores the potential of computational models as noninvasive, clinically feasible tools for assessing in-depth pulmonary vascular and RV function in PH.
Lechuga et al. (Mon,) studied this question.