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Dysregulation of Serpinb6a-Gch1 axis contributes to DFNB91 deafness that is amendable to gene therapies | Synapse
March 3, 2026
Dysregulation of Serpinb6a-Gch1 axis contributes to DFNB91 deafness that is amendable to gene therapies
CC
Cheng Cheng
Nanjing Drum Tower Hospital
LZ
Liyan Zhang
Inner Mongolia Medical University
JL
Jie Lu
Nanjing Drum Tower Hospital
Ver todo
Puntos clave
DFNB91 deafness is linked to dysregulation of the serpinb6a-gch1 axis, impacting hearing.
Key evidence shows that targeting this axis may allow intervention through gene therapies.
Analysis of genetic pathways suggests that correcting the serpinb6a-gch1 dysregulation could improve hearing outcomes.
Further investigation into this axis highlights potential strategies for treating DFNB91 deafness.
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Cite This Study
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Cheng et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75e2ec6e9836116a2896a
https://doi.org/https://doi.org/10.1016/j.ymthe.2026.01.030