Yu L, Lemay P, Ludlow A, et al. A new murine Rpl5 ( uL18 ) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia. Blood Adv . 2021;5(20):4167-4178. | Synapse
March 3, 2026Open Access
Yu L, Lemay P, Ludlow A, et al. A new murine Rpl5 ( uL18 ) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia. Blood Adv . 2021;5(20):4167-4178.
Puntos clave
Variably penetrant Diamond-Blackfan anemia is modeled using a new murine rpl5 mutation.
This model shows distinct features of erythropoiesis, highlighting its relevance to understanding the disease.
Assessment using genetic analysis reveals insights into the mechanisms of the rpl5 mutation in mice.
Understanding this model may enable better therapeutic approaches for genetically influenced anemia.