This research investigates the effectiveness of nickel-catalyzed Suzuki–Miyaura reactions in continuous flow for API synthesis.
Optimized Ni-catalyzed Suzuki–Miyaura reactions using continuous flow.
Applied methodology to synthesize complex APIs.
Explored sustainability in chemical processes.
Achieved efficient synthesis of savolitinib and baxdrostat using continuous flow.
Demonstrated the versatility of a sustainable methodology for cross-couplings.
Resumen
Exploiting continuous flow for optimising Ni-catalyzed Suzuki–Miyaura reactions; a versatile, sustainable methodology translated directly to the synthesis of complex APIs savolitinib and baxdrostat.