Background: Ayurveda, the ancient Indian medical science, emphasizes personalized therapeutics wherein Anupana-the co-administered adjuvant or vehicle taken along with or immediately after the medicine-plays a vital pharmacological role. Anupana modulates a drug’s efficacy, potency, bioavailability, and safety through its influence on Rasa, Guna, Veerya, Vipaka, and Prabhava. Objective: This review explores the pharmacological significance of Anupana through a comparative evaluation of classical Ayurvedic insights and contemporary pharmacological evidence, highlighting its potential relevance for modern drug delivery systems and personalized medicine. Methodology: A structured textual and literature review was conducted using Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, Bhavaprakasha Nighantu, Rasa Tarangini, and Sharangadhara Samhita, alongside PubMed-indexed research on bioenhancers, lipid carriers, and adjuvants. Qualitative analysis was employed to correlate traditional descriptions with pharmacokinetic and pharmacodynamic principles. Results: Classical Ayurvedic sources describe Anupana as a therapeutic modulator that directs drug action, enhances Veerya, and minimizes toxicity. Substances like ghee, milk, honey, and warm water are recommended contextually based on Dosha, disease type, season, and Agni Bala. Modern research validates these properties-ghee as a lipophilic carrier, honey as a synergistic bioenhancer, and piperine as a metabolic modulator enhancing bioavailability of curcumin. In Rasa Shastra, Anupana ensures safe administration of potent herbo-mineral drugs, preventing oxidative toxicity. Conclusion: Anupana represents a sophisticated pharmacological concept that anticipates modern drug carrier and bioenhancer theories. Its classical basis aligns closely with pharmacokinetic processes like absorption, metabolism, and distribution.
1*Ashish Moda, 2Shibabrata Behera, 3Krishna Mohanty (2026) studied this question.