What question did this study set out to answer?

This research investigates the interactions between trehalose and proteins in water, focusing on how trehalose stabilizes proteins.

March 21, 2026Open Access

The nature of trehalose–protein interactions in aqueous solutions revealed by neutron scattering

Puntos clave

This research investigates the interactions between trehalose and proteins in water, focusing on how trehalose stabilizes proteins.
Utilized neutron scattering to observe protein and trehalose interactions in aqueous solutions.
Analyzed the structural changes in proteins when exposed to trehalose under varying conditions.
Trehalose effectively interacts with proteins, aiding in their stabilization during dehydration.
The findings suggest that exclusion of trehalose from the protein surface plays a crucial role in stabilization.

Resumen

Trehalose is widely recognized for stabilising proteins under conditions that promote dehydration, denaturation, or loss of function, yet its underlying mechanisms remain elusive, although exclusion from the protein surface may be of importance.

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Cite This Study

Ahlgren et al. (Thu,) studied this question.

synapsesocial.com/papers/69be37726e48c4981c6770e1 https://doi.org/https://doi.org/10.1039/d5nr05299h

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