What question did this study set out to answer?

The aim is to evaluate the antihypertensive potential of bioactive peptide fractions from Vigna unguiculata.

March 21, 2026

Bioactive peptide fractions from Vigna unguiculata : Inhibition kinetics, gastrointestinal stability, cytotoxicity assessment, and amino acid profile as compositional features associated with antihypertensive activity

Puntos clave

The aim is to evaluate the antihypertensive potential of bioactive peptide fractions from Vigna unguiculata.
Analyzed peptide fractions for ACE-I inhibition
Assessed gastrointestinal stability under digestive conditions
Evaluated cytotoxicity levels of the peptides
Characterized amino acid profile of the fractions
Peptide fractions showed non-competitive inhibition of ACE-I
Demonstrated high stability during digestion
Exhibited low levels of cytotoxicity
Identified relevant amino acids associated with antihypertensive effects

Resumen

The <1 kDa-PP V. unguiculata peptide fractions combine non-competitive ACE-I inhibition, high digestive stability, and low cytotoxicity, presenting potential as antihypertensive ingredients in functional foods and nutraceuticals. These findings warrant further investigation, including the identification of sequences within the active fractions and in vivo validation of antihypertensive efficacy. © 2026 Society of Chemical Industry.

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Discussion

Journals

Journal of the Science of Food and Agriculture

Institutions

National University of the Littoral

Universidad Marista de Mérida

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