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January 9, 2012Arthritis & Rheumatism149 citations

DNA demethylation of CD40L in CD4+ T cells from women with systemic sclerosis: A possible explanation for female susceptibility

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XLXiao-ri LianRXRong XiaoXHXinhong Hu

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Abstract

Demethylation of CD40L regulatory elements on the inactive X chromosome contributes to CD40L overexpression in CD4+ T cells from female patients with SSc.

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Cite This Study

Lian et al. (2012) studied this question.

synapsesocial.com/papers/69d6b59d733a2b54c8aa81d2https://doi.org/10.1002/art.34376
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1X chromosome inactivation and DNA methylation1993 · 78 citations
  2. 2Sex differences in autoimmune disease2001 · 1,277 citations
  3. 3Increased Expression of CD40 Ligand in Activated CD4+T Lymphocytes of Systemic Sclerosis Patients2000 · 44 citations
  4. 4The CD40 Antigen and its Ligand1994 · 1,264 citations
  5. 5Gene Action in the X-chromosome of the Mouse (Mus musculus L.)1961 · 4,038 citations