What question did this study set out to answer?

The central aim is to understand how neutrophil extracellular traps (NETs) contribute to organ injury in complement-mediated thrombotic microangiopathy (TMA).

April 10, 2026

Neutrophil Extracellular Traps Aggravate Injury in Complement-Mediated Thrombotic Microangiopathy

Puntos clave

The central aim is to understand how neutrophil extracellular traps (NETs) contribute to organ injury in complement-mediated thrombotic microangiopathy (TMA).
Assessment of NETs biomarkers in patients with complement-mediated TMA.
Evaluation of CD59 shedding from human renal glomerular endothelial cells (HRGECs).
Analysis of the relationship between NETs and complement activation as well as coagulation processes.
Increased levels of NETs biomarkers were observed in cases of complement-mediated TMA.
NETs contributed to organ injury by shedding CD59 from HRGECs, which enhanced complement activation.
NETs were linked to the activation of coagulation pathways.

Resumen

Levels of NETs biomarkers increased in complement-mediated TMA and drove multi-organ injury by shedding CD59 from HRGECs to enhance complement activation and participate in coagulation activation.

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Authors

Xiao-tian Liu

Zi-xin Hua

Meng Tan

Journals

Journal of the American Society of Nephrology

Actions

Institutions

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University International Hospital

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Neutrophil Extracellular Traps Aggravate Injury in Complement-Mediated Thrombotic Microangiopathy

Puntos clave

Resumen

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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