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April 10, 2026

Integrative multi‐omics suggests core gene dysregulation of histidine metabolism in diabetic kidney disease

Puntos clave

This research explores the dysregulation of histidine metabolism in diabetic kidney disease through multi-omics approaches.
Conducted multi-omics analyses to assess metabolomic and genomic data.
Integrated various omics data to identify dysregulation pathways.
Focused on histidine metabolism and its implications in diabetic kidney disease.
Histidine metabolism shows significant dysregulation in diabetic kidney disease.
Identified key genes involved in histidine metabolism that may represent potential therapeutic targets.
Proposed novel mechanistic insights related to pathological events in diabetic kidney disease.

Resumen

By integrating multi-omics analyses, we suggest that histidine metabolic reprogramming represents a PT pathological event in DKD, providing novel mechanistic insights and potential therapeutic targets.

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Cite This Study

Tan et al. (Tue,) studied this question.

synapsesocial.com/papers/69d895486c1944d70ce064a3 https://doi.org/https://doi.org/10.1111/dme.70238

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