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January 17, 2020International Journal of Molecular SciencesOpen Access

Metabolic disorders such as obesity and T2DM contribute to platelet hyperaggregability and hyperactivation through mechanisms including elevated clinical platelet markers and reduced sensitivity to mediators like nitric oxide and prostacyclin.

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Why the study?

Metabolic disorders alter platelet function and increase atherothrombotic risk, but the specific mechanisms linking cardiometabolic risk factors to platelet hyperactivation require review.

How do cardiometabolic risk factors influence platelet function and contribute to a prothrombotic tendency?

Design

Review

Authors

CBCristina BaraleIRIsabella Russo

Discussion

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Member takes

Overview

Alerts clinicians to prothrombotic platelet changes in obesity/T2DM; leaves open targeted interventions pending prospective trials.

Structured PICO

How do cardiometabolic risk factors influence platelet function and contribute to a prothrombotic tendency?

P
Population
Patients with cardiometabolic risk factors including obesity, type 2 diabetes (T2DM), insulin resistance, dyslipidemia, and hypertension
O
Outcome
Alterations of platelet function resulting in platelet hyperactivation and prothrombotic tendencysurrogate

Cardiometabolic risk factors, including obesity and T2DM, drive a prothrombotic state through specific alterations in platelet function, highlighting the intersection between metabolic syndrome, inflammation, and thrombosis.

Cite This Study

Barale et al. (2020) studied this question.

synapsesocial.com/papers/69d90940cc20f7a91c3afd91https://doi.org/10.3390/ijms21020623
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