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April 13, 2026Clinical Chemistry and Laboratory Medicine (CCLM)

A simplified multitarget stool test for colorectal cancer and advanced precancerous lesion detection

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Authors

SXShuizhi XuLGLiang GongYLYi Lu

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Overview

Demonstrates a new stool test for detecting colorectal cancer and advanced lesions, indicating improved screening efficacy.

Key Points

  • The aim is to evaluate a simplified multitarget stool test for detecting colorectal cancer and advanced precancerous lesions.
  • Conducted a multitarget stool test using fecal immunochemical test and DNA methylation markers NDRG4 and SDC2.
  • Assigned scores (0, 1, or 2) based on the positivity of biomarkers for each participant.
  • Utilized age-dependent cut-off values for analyses.
  • Achieved 90.0% sensitivity for colorectal cancer detection and 65.2% for advanced precancerous lesions.
  • Specificity was 91.0% for negative colonoscopy participants and 90.9% for those without advanced neoplasia.
  • Observed a decline in specificity with age, which was reduced using age-adjusted cut-offs.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69dc887f3afacbeac03ea55dhttps://doi.org/10.1515/cclm-2026-0236
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