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April 13, 2026Cancer Cell InternationalOpen Access

SETDB1 promotes gastric cancer progression via UPR and mTOR pathway

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Authors

JQJing QiaoSLShijie LinYLYeju Li

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Overview

Experimental analyses identify SETDB1's role in promoting gastric cancer cell growth and movement, indicating a potential treatment target.

Key Points

  • This research investigates the role of SETDB1 in gastric cancer progression and its underlying mechanisms.
  • Utilized molecular and cell biology techniques.
  • Compared SETDB1 expression in gastric cancer tissues versus adjacent non-tumor tissues.
  • Conducted RNA sequencing and RNC-mRNA sequencing.
  • Performed functional assays after SETDB1 knockdown and overexpression.
  • SETDB1 was significantly overexpressed in gastric cancer tissues.
  • Knockdown of SETDB1 decreased cell proliferation and migration in gastric cancer.
  • SETDB1 promoted cell proliferation independently of its enzymatic activity.
  • Cell migration required SETDB1's methyltransferase function.
  • SETDB1 activated UPR to enhance c-MYC transcription and engaged the mTOR-4EBP1 axis for HIF1α translation.

Cite This Study

Qiao et al. (2026) studied this question.

synapsesocial.com/papers/69dc88f43afacbeac03eabcfhttps://doi.org/10.1186/s12935-026-04296-1
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