Novel NHC-based Pd–PEPPSI complexes: synthesis, structural characterization by X-ray diffraction, biological properties, and catalytic performance in N -alkylation reactions | Synapse
April 15, 2026Open Access
Novel NHC-based Pd–PEPPSI complexes: synthesis, structural characterization by X-ray diffraction, biological properties, and catalytic performance in N -alkylation reactions
Puntos clave
To explore the synthesis and catalytic properties of novel Pd-PEPPSI-NHC complexes for N-alkylation reactions.
Synthesized Pd-PEPPSI-NHC complexes
Characterized structures using X-ray diffraction
Evaluated catalytic performance in N-alkylation of amines and alcohols
Successfully performed N-alkylation using Pd-PEPPSI-NHC complexes
Demonstrated effectiveness in the borrowing-hydrogen approach
First report of this catalyst class in N-alkylation transformations
Resumen
Herein, we describe the borrowing-hydrogen N -alkylation of amines with alcohols using Pd-PEPPSI-NHC complexes, representing the first example of this catalyst class applied to this transformation.