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April 17, 2026BMJ Case Reports0 citations

Primary orbital B cell lymphoblastic lymphoma in a toddler mimicking rhabdomyosarcoma: a diagnostic challenge

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BPBijnya Birajita PandaAll India Institute of Medical Sciences BhubaneswarDSDebasish SahooAll India Institute of Medical Sciences BhubaneswarSMSonali MohapatraAll India Institute of Medical Sciences Bhubaneswar

Key Points

  • To highlight the diagnostic difficulties in distinguishing primary orbital B cell lymphoblastic lymphoma from rhabdomyosarcoma in young children.
  • Case study of a toddler with an orbital mass
  • Utilized histopathology for confirmation
  • Conducted immunophenotyping to identify lymphoma type
  • Initial misdiagnosis as rhabdomyosarcoma
  • Confirmed diagnosis of B cell lymphoblastic lymphoma through histopathology
  • Emphasized the need for careful evaluation of orbital lesions in pediatric patients

Abstract

Paediatric orbital tumours are rare, and primary orbital lymphomas are particularly uncommon, with an incidence of approximately 0.12 per 1000 000 children. Such lymphomas may present as orbital cellulitis, sinonasal or orbital masses. Due to overlapping clinical and radiological features, these cases are often misdiagnosed initially, with rhabdomyosarcoma being a common provisional diagnosis. We report a rare case of primary orbital B cell lymphoblastic lymphoma in a toddler, initially misdiagnosed as rhabdomyosarcoma, later confirmed via histopathology and immunophenotyping.

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Cite This Study

Panda et al. (2026) studied this question.

synapsesocial.com/papers/69e1cffa5cdc762e9d858f5ahttps://doi.org/10.1136/bcr-2025-264952
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