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April 27, 2026Lara D. Veeken0 citationsOpen Access

Ultrasonographic evaluation of familial Mediterranean fever patients with exertional leg pain: an overlooked component of the disease

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BKBatuhan KüçükaliÇYÇişem YıldızNBNuran Belder

Key Points

  • This research aims to assess achilles tendon thickness and knee effusions in FMF patients experiencing exertional leg pain.
  • Evaluated pediatric patients with familial Mediterranean fever (FMF) who reported exertional leg pain (ELP).
  • Measured achilles tendon thickness and knee effusions via ultrasonography.
  • Proposed that findings reflect underlying subclinical inflammation associated with ELP.
  • Patients with ELP showed increased achilles tendon thickness compared to those without ELP.
  • Inter-attack knee effusions were identified as potential markers for subclinical inflammation in FMF patients.
  • Further research with larger cohorts is needed to clarify the clinical significance of observed changes.

Abstract

Pediatric FMF patients with ELP demonstrated increased achilles tendon thickness. Although no standardized cut-off exists for tendinopathy, this may reflect tendon structural changes related to ELP. Moreover, FMF patients, particularly those with ELP, exhibited inter-attack knee effusions which may serve as a marker for subclinical inflammation. Larger longitudinal cohorts are needed to define ELP, elucidate its underlying pathways and clarify the clinical significance of Achilles tendon thickening.

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Cite This Study

Küçükali et al. (2026) studied this question.

synapsesocial.com/papers/69eefd9bfede9185760d45c8https://doi.org/10.1093/rheumatology/keag226
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