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May 3, 2026

TCRbeta1/TCRbeta2 (TRBC1/TRBC2) antibody pair for determining T-cell monotypia as a surrogate for clonality in formalin-fixed paraffin-embedded material.

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Authors

AKAnuradha KaisthaJSJinlong J SituSEShelley Evans

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Overview

Randomized trial demonstrates T-cell monotypia detection using novel immunohistochemical assay, suggesting improved diagnostics for lymphomas.

Key Points

  • The study aims to develop a new immunohistochemical test using monoclonal antibodies for T-cell lymphoma diagnosis.
  • Developed monoclonal antibodies against TCRβ1 and TCRβ2.
  • Conducted immunohistochemical detection on formalin-fixed, paraffin-embedded tissues.
  • Tested the assay on 13 T-cell lymphomas and 8 benign T-cell infiltrates.
  • Successful immunostaining for both TCRβ1 and TCRβ2 presented in T-cell lymphomas and benign populations.
  • The assay allows accurate calculation of the TCRβ2:TCRβ1 ratio through automated counting.
  • Demonstrated feasibility as a diagnostic tool analogous to the kappa/lambda assay for B-cell neoplasms.

Cite This Study

Kaistha et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5cf8071d4f1bdfc66fbhttps://doi.org/10.1136/jcp-2026-210684
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