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May 3, 2026

Unexpected Mechanisms of Repurposed Drugs in the Pathogenic Pathways of Neurodegenerative Diseases. Discovering New Neuroprotective Therapies in Cellular Models.

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Authors

MAM S Arasmou-IdrovoBMB Marín-RodríguezAGA Gironda-Martínez

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Overview

Randomized trial evaluates neuroprotective effects of repurposed drugs in cellular models, suggesting new therapies.

Key Points

  • The aim is to discover new neuroprotective therapies targeting common pathways in neurodegenerative diseases.
  • Applied a drug-repurposing pipeline using in vitro validation in SH-SY5Y and HEK293 cells.
  • Screened eight clinically approved CNS drugs for activity against specific calcium channels.
  • Evaluated drug efficacy in neuroprotection assays.
  • Chlorpromazine showed broad-spectrum neuroprotection and antagonism of Caᵥ1.2 and P2X7 (exact metrics not provided).
  • Trimipramine acted as a potent antioxidant and demonstrated significant neuroprotective effects.
  • Vilazodone exhibited synergistic effects when combined with procyclidine in neuroprotection assays.

Cite This Study

Arasmou-Idrovo et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5cf8071d4f1bdfc67dehttps://doi.org/10.1016/j.neuropharm.2026.110994
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