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May 3, 20260 citations

Auditory Hair Cell Orientation Correction Without Core PCP and GPR156 Signaling

Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling.

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Authors

AJAmandine JarystaJNJustin NemelkaMRMuthumeena Ramanathan

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Overview

Randomized trial investigates the role of GPR156 in auditory hair cell orientation, revealing plasticity in defect correction.

Key Points

  • The central aim is to understand how auditory hair cells correct orientation defects without core planar cell polarity signaling.
  • Used viable conditional mutants lacking Vangl1/Vangl2 or Frizzled3/Frizzled6.
  • Examined postnatal reorientation of misoriented auditory hair cells.
  • Analyzed the role of GPR156 in the recovery of orientation defects.
  • Misoriented hair cells showed substantial correction over time postnatally.
  • GPR156 is essential for orientation but inhibits correction in core PCP mutant contexts.
  • Inhibition of GPR156 signaling facilitated correction in Vangl and Frizzled mutants.

Cite This Study

Jarysta et al. (2026) studied this question.

synapsesocial.com/papers/69f6e67c8071d4f1bdfc71fbhttps://doi.org/10.1242/dev.205332
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