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May 6, 2026Circulation

Longitudinal VAT gain linked to metabolic dysregulation via changes in 34 inflammatory proteins.

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Why the study?

How changes in visceral adipose tissue modulate circulating inflammatory proteins and interact with glycemic control remains unclear.

Are longitudinal changes in visceral adipose tissue and glycemic control associated with changes in inflammatory proteomic profiles in middle- to older-aged adults?

Population

562 middle- to older-aged US adults in the VITAL study

Comparison

Longitudinal changes in VAT mass and glycemic traits

Design

Prospective cohort study

Follow-up

2 years

Key result

Longitudinal gain in visceral adipose tissue over 2 years was significantly associated with concurrent changes in 34 inflammatory proteins (FDR<0.05), linking VAT change to metabolic dysregulation.

Authors

CWCong WangAYAzam YazdaniODO Demler

Discussion

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Overview

Reassures clinicians on short-term VAT and glycemic trajectories in at-risk adults; leaves open mediating role of inflammatory proteomics.

Key Points

  • This study investigates how changes in visceral adipose tissue influence glycemic control and inflammatory profiles over time.
  • Analyzed data from 562 participants in the VITAL study over 2 years.
  • Assessed changes in visceral adipose tissue, glycemic traits, and inflammatory protein levels.
  • Used multivariable linear models to evaluate associations among changes in VAT and glycemic traits.
  • Participants showed non-significant increases in VAT mass (mean=9.1g, p=0.66) and glucose (mean=1.26mg/dL, p=0.09).
  • Significant associations found between VAT gain and changes in 34 inflammatory proteins (FDR<0.05).
  • Distinct proteomic changes linked to glycerol control, indicating VAT's role in metabolic dysregulation and inflammation.

Study Design

Type

Cohort (n=562)

Structured PICO

Are longitudinal changes in visceral adipose tissue and glycemic control associated with changes in inflammatory proteomic profiles in middle- to older-aged adults?

P
Population
562 middle- to older-aged US adults (mean age 63.7±6.1) from the prospective VITAL study
I
Intervention
Longitudinal changes in DXA-derived visceral adipose tissue (VAT) mass and glycemic traits (fasting glucose, HbA1c, HOMA-IR)
O
Outcome
Associations of within-person 2-year changes in VAT and glycemic traits with individual changes in inflammatory proteins (Olink Explore 384 inflammation panel)surrogate

Main Result

p-value: p=<0.05 (FDR)

Longitudinal changes in visceral adiposity and glycemic control are associated with distinct inflammatory proteomic changes, highlighting a biological link between VAT, metabolic dysregulation, and inflammation.

Cite This Study

Wang et al. (2026) conducted a cohort in Obesity and risk of T2D and CVD (n=562). Longitudinal changes in visceral adipose tissue (VAT) was evaluated on Associations between 2-year changes in VAT and individual inflammatory proteins (p=<0.05 (FDR)). Longitudinal gain in visceral adipose tissue over 2 years was significantly associated with concurrent changes in 34 inflammatory proteins (FDR<0.05), linking VAT change to metabolic dysregulation.

synapsesocial.com/papers/69fadaab03f892aec9b1e61dhttps://doi.org/10.1161/cir.153.suppl_1.we525
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