Randomized trial examines the impact of brain region stimulation on anxiety in chronic rhinosinusitis patients, suggesting a neural-immune link.
Key Points
The aim is to investigate the specific brain regions involved in anxiety related to chronic rhinosinusitis and the underlying neural-immune mechanisms.
Evaluated anxiety symptoms in chronic rhinosinusitis patients using the Hospital Anxiety and Depression Scale (HADS).
Established a papain-induced chronic rhinosinusitis mouse model to assess anxiety-like behaviors and brain alterations.
Used immunohistochemistry, fiber photometry, and chemogenetic techniques to study neural activity and interactions.
Persistent anxiety-like behaviors were observed in chronic rhinosinusitis patients and mice, even with reduced sinonasal inflammation.
CRS mice showed hyperactivation of BLA CaMKIIα-positive neurons associated with increased excitatory synaptic input.
Inhibition of BLA neurons reduced anxiety-like behaviors, inflammatory markers, and norepinephrine release.