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September 19, 2025Journal of the American Chemical SocietyOpen Access

Seq2Saccharide: Discovering Oligosaccharides and Aminoglycosides Natural Products by Integrating Computational Mass Spectrometry and Genome Mining

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Authors

DYDonghui YanBBBahar BehsazYLYanjing Li

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Overview

Observational analysis improves structure prediction of oligosaccharides using computational mass spectrometry and genome mining.

Key Points

  • Seq2Saccharide significantly enhances the prediction of oligosaccharide structures by leveraging genomic and mass spectrometry data, achieving greater accuracy.
  • Benchmarks show that Seq2Saccharide outperforms existing methods, highlighting its efficacy in natural product discovery.
  • Integration of diverse data sets allows Seq2Saccharide to generate thousands of potential structures, improving the identification process.
  • The system's variable search module corrects mispredictions, further refining the outcomes of genome mining.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68d46cd731b076d99fa695e2https://doi.org/10.1021/jacs.5c08251
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