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Reduced circulating levels of nitric oxide metabolites are hypothesized, in part, to drive hypertension in autosomal dominant polycystic kidney disease (ADPKD).1 Beetroot juice (BRJ), a rich dietary source of nitrate, increases nitric oxide metabolites via the entero-salivary nitrate-nitrite-NO pathway, and lowers blood pressure (BP).2 In the largest randomized controlled trial of 68 hypertensive patients, nitrate-replete BRJ reduced systolic BP by a mean of 9.0 ± 7.8 mm Hg after 4-weeks compared to 0.1 ± 8.0 mm Hg in the nitrate-deplete BRJ group.
Sagar et al. (2024) studied this question.