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Synapse
February 27, 2026Open Access

Metabolic Competition Between Microglia and Neurons as Driver of Chronic Pain

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Authors

EAEnso Onill Torres AlegreDMDiana Paola Duarte Mora

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Overview

This research proposes metabolic competition influences chronic pain in a novel way, suggesting new treatment avenues.

Key Points

  • The aim is to explore how metabolic competition between microglia and neurons contributes to chronic pain.
  • Proposed framework integrating neuroimmunology and metabolic neurobiology.
  • Utilized advances in immunometabolism and single-cell/spatial metabolomics.
  • Suggested in vivo biosensor imaging for experimental validation.
  • Proposed shifts in energy allocation could affect neuronal excitability.
  • Identified glucose, lactate, and NAD+ as critical factors in chronic pain.
  • Predicted metabolic reprogramming as a potential therapeutic target for chronic pain.

Cite This Study

Alegre et al. (2026) studied this question.

synapsesocial.com/papers/69a135b0ed1d949a99abfbe9https://doi.org/10.5281/zenodo.18777634
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