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March 8, 2026SHILAP Revista de lepidopterologíaOpen Access

Effect of oliceridine pretreatment on etomidate-induced myoclonus: a prospective, randomized, double-blind, controlled study

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Authors

QSQingqing SunXWXiaoqian WangZCZiyuan Chen

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Overview

This randomized trial demonstrates lower myoclonus incidence with oliceridine pretreatment in surgical patients, suggesting a safer anesthesia approach.

Key Points

  • This study aims to evaluate the effect of oliceridine pretreatment on the occurrence of etomidate-induced myoclonus during anesthesia.
  • Prospective, randomized, double-blind, controlled design.
  • Patients were divided into an oliceridine group (0.02 mg/kg) and a saline group.
  • Oliceridine or saline was administered 2 minutes before etomidate.
  • Primary outcome: incidence of etomidate-induced myoclonus.
  • Secondary outcomes included severity of myoclonus, adverse reactions, and hemodynamic changes.
  • Myoclonus incidence was significantly lower in the oliceridine group (13.3%) compared to the saline group (51.1%).
  • Severity of myoclonus was considerably reduced in the oliceridine group.
  • Time to loss of consciousness was faster in the oliceridine group (43.24 s) compared to the saline group (48.2 s).
  • There were no significant differences in adverse reactions or hemodynamic changes between the groups.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69ada836bc08abd80d5bb437https://doi.org/10.3389/fmed.2026.1764143
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