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April 16, 2026Neuromodulation Technology at the Neural Interface0 citationsOpen Access

Moving From Prefrontal 10-Hz Repetitive Transcranial Magnetic Stimulation to Intermittent Theta-Burst Stimulation in Adults With Depression: Retrospective Comparison of Naturalistic Data

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HSHilde SteinbeckLTLisa TagninCKCarolin A.M. Koriath

Key Points

  • The research evaluates the efficacy of 10-Hz repetitive transcranial magnetic stimulation (rTMS) compared to intermittent theta-burst stimulation (iTBS) for treating depression.
  • Retrospective analysis of real-world data from clinical settings.
  • Comparison of response rates between 10-Hz rTMS and iTBS protocols.
  • Assessment of clinical efficacy against randomized clinical trials (RCTs).
  • Both 10-Hz rTMS and iTBS showed clinically relevant response rates.
  • iTBS demonstrated greater time efficiency than 10-Hz protocols.
  • Efficacy of both interventions was comparable to recent RCT findings.

Abstract

RWD may serve as valuable comparator to results from randomized, clinical trials (RCTs). The results in our clinical sample indicate clinically relevant response rates with comparative efficacy for both, 10Hz and iTBS protocols. Both protocols were comparable to recent RCTs in terms of clinical efficacy. With comparable efficacy to 10 Hz and greater time efficiency, iTBS is an established, pragmatic, and scalable treatment option in real-world clinical settings.

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Cite This Study

Steinbeck et al. (2026) studied this question.

synapsesocial.com/papers/69e07cfa2f7e8953b7cbdfb1https://doi.org/10.1016/j.neurom.2026.02.009
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