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April 19, 2026Experimental Gerontology0 citationsOpen Access

From vessels to cognition: The mediating role of biological aging in the cognitive trajectory of diabetic patients

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WCWei ChengJLJiangtao LiFSFuchen Song

Key Points

  • This research aims to investigate how biological aging impacts cognitive decline in diabetic individuals due to vascular stiffness.
  • Analyzed baseline ePWV levels in diabetic patients.
  • Monitored cognitive trajectories over a 9-year period.
  • Assessed the mediating role of biological aging on cognitive performance.
  • Elevated baseline ePWV is a predictor of low cognitive trajectory.
  • Biological aging partially mediates the relationship between vascular stiffness and cognitive decline.
  • Patients with higher ePWV exhibited accelerated cognitive deterioration over the years.

Abstract

In diabetic patients, elevated baseline ePWV is an independent predictor of a persistently low cognitive trajectory over a 9-year period. This association appears to be partially mediated by accelerated biological aging, suggesting that vascular stiffness may act as a systemic driver of cognitive compromise.

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Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/69e4702d010ef96374d8d64bhttps://doi.org/10.1016/j.exger.2026.113135
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