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May 7, 2026Journal of General Virology0 citationsOpen Access

Copper(II) Benzyloxychalcone Analogues as Potential Metallodrugs Against SARS-CoV-2

Copper(II) benzyloxychalcone analogues as new potential metallodrugs against SARS-CoV-2 replication

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Authors

ISIgor Andrade SantosVGVictória Riquena GroscheLOLaiane dos Santos Oliveira

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Overview

Experimental findings reveal mechanistic insights of a Cu(II) metallodrug in SARS-CoV-2 infection, suggesting therapeutic potential.

Key Points

  • This research aims to explore the activity of copper(II) benzyloxychalcone analogues in inhibiting SARS-CoV-2 replication.
  • Evaluated the effects of Cu(II) benzyloxychalcone analogues on SARS-CoV-2 entry and RNA replication.
  • Investigated the mechanism of action involving disruption of the viral envelope and dsRNA intercalation.
  • Demonstrated that Cu(II) benzyloxychalcone analogues impair SARS-CoV-2 entry.
  • Interfered with RNA replication by intercalating into dsRNA, suggesting a dual mechanism of action.

Cite This Study

Santos et al. (2026) studied this question.

synapsesocial.com/papers/69fc2ca48b49bacb8b34812ahttps://doi.org/10.1099/jgv.0.002245
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