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March 1, 2002The American Journal of GastroenterologyOpen Access

Semiannual and Annual Surveillance of Cirrhotic Patients for Hepatocellular Carcinoma: Effects on Cancer Stage and Patient Survival (Italian Experience)

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Authors

FTFranco TrevisaniSNStefania De NotariisGRGianludovico Rapaccini

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Overview

Randomized trial examines cancer stage and patient survival in cirrhotic individuals, suggesting surveillance benefits.

Key Points

  • The aim is to evaluate the impact of surveillance on cancer stage and survival of cirrhotic patients diagnosed with hepatocellular carcinoma.
  • Multicenter retrospective study involving 1051 patients with hepatocellular carcinoma.
  • Analyzed groups based on the timing of surveillance (semiannual vs. annual vs. symptomatic detection).
  • Survival adjusted for lead time across different stages of cirrhosis.
  • Cancer stage was less advanced in patients monitored semiannually and annually compared to those diagnosed symptomatically (p < 0.001).
  • Survival rates after 5 years were greater in groups under surveillance compared to symptomatic patients (p < 0.001).
  • Surveillance doubled the eligibility for liver transplantation candidates compared to symptomatic patients (68.5% vs. 32.3%, p < 0.001).

Cite This Study

Trevisani et al. (2002) studied this question.

synapsesocial.com/papers/6a0672c4f2cf2ebbc4025540https://doi.org/10.1111/j.1572-0241.2002.05557.x
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