Randomized trial identifies AKI disparities in pediatric leukemia based on race/ethnicity and neighborhood resources, suggesting a need for targeted interventions.
Key Points
The aim is to identify racial, ethnic, and neighborhood disparities in acute kidney injury (AKI) among children with leukemia.
Retrospective analysis of electronic health records from pediatric ALL and AML patients
Calculated prevalence ratios (PRs) and hazard ratios (HRs) using Poisson and Cox regression
Defined neighborhood resources using Child Opportunity Level (COL)
Non-Hispanic Black (NHB) ALL patients had a higher prevalence of AKI at diagnosis compared to Non-Hispanic White (NHW) with PR 1.50
NHB AML patients showed a significantly higher risk of AKI during therapy with HR 2.68 in adjusted models
No significant differences in AKI prevalence were found by COL for both ALL and AML.