Experimental analysis reveals the role of interleukin-6 in chemotherapy-induced peripheral neurotoxicity in rats, suggesting potential therapeutic targets.
Key Points
This research aims to understand the role of interleukin-6 and macrophages in chemotherapy-induced peripheral neurotoxicity in rat models.
Comparison of paclitaxel (PTX) and oxaliplatin (OHP) treatments in rat models.
Behavioral tests and pathological analysis to assess CIPN symptoms.
Assessment of serum cytokines and gene expression in dorsal root ganglia and nerves.
Notable differences in macrophage infiltration were observed between PTX- and OHP-treated rats.
IL-6, CCL2, and CXCL1 exhibited distinct expression patterns in response to the treatments.
Increased upregulation of pro-inflammatory markers was linked to PTX treatment, with implications for CIPN.