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February 2, 2026Age and Ageing3 citationsOpen Access

Temporal Dynamics of Blood Pressure, Functional Status, and Cognitive Function in Elderly Adults

Temporal dynamics of blood pressure, functional status and cognitive function in adults aged 85 years and older: a dynamic time warping approach in the Leiden 85-plus study

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Authors

JDJ.J. DuinSTStella TrompetEGE. Giltay

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Overview

Dynamic analysis explores relationships between blood pressure, functional status, and cognitive function in very old adults, suggesting potential predictive markers.

Key Points

  • This study aims to investigate the relationships between blood pressure changes and functional and cognitive status in individuals aged 85 and older.
  • Analyzed data from the Leiden 85-plus Study over 5 years.
  • Measured blood pressure, functional status, and cognitive function annually.
  • Included participants with at least three measurements (n = 429).
  • Utilized dynamic time warping to assess temporal relationships.
  • Increases in blood pressure correlated with later declines in instrumental activities of daily living (IADL).
  • Decreases in blood pressure were associated with improvements in IADL over time.
  • Decreases in diastolic blood pressure linked to declines in cognitive function as measured by the MMSE.
  • Increases in diastolic blood pressure corresponded with improvements in MMSE scores.
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Cite This Study

Duin et al. (2026) studied this question.

synapsesocial.com/papers/6980fc91c1c9540dea80e628https://doi.org/10.1093/ageing/afag006
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