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February 17, 2026iMetaOmics.Open Access

Microbiome‐urothelium crosstalk in bladder cancer: From dysbiosis to clinical translation

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Authors

HXHaoxiang XuZLZhibiao LiLYLin Yang

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Overview

This review examines microbiome involvement in bladder cancer, suggesting its potential as a biomarker for treatment responses.

Key Points

  • The aim is to investigate the role of the urinary microbiome in bladder cancer and its implications for treatment.
  • Reviewed current literature on urinary microbial signatures in bladder cancer and healthy states.
  • Analyzed mechanisms of microbiota influence on carcinogenesis and therapeutic response.
  • Discussed potential translational applications of urobiome profiling as biomarkers.
  • Distinct urinary microbial signatures differentiate healthy individuals from bladder cancer patients.
  • Microbiota dysbiosis is implicated in bladder cancer pathogenesis and progression.
  • Urinary microbiota profiling may predict treatment responses and stratify risk in bladder cancer patients.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6994058c4e9c9e835dfd6832https://doi.org/10.1002/imo2.70081
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Urine Trouble: Reducing Midstream Clean Catch Urine Contamination Among Children 3–17 Years Old2021 · 4 citations
  2. 2Temporal Dynamics of the Human Vaginal Microbiota2012 · 1,658 citations
  3. 3Association of bacteriuria and urinary nitrosamine formation with Schistosoma haematobium infection in the Qalyub area of Egypt1982 · 78 citations
  4. 4URINARY TRACT INFECTION AND RISK OF BLADDER CANCER1984 · 277 citations
  5. 5Urinary microbiota – a potential biomarker and therapeutic target for bladder cancer2019 · 109 citations