Abstract PS5-10-04: Willingness to participate in a trial comparing standard genetic counseling versus genetic counseling with personalized cancer risk estimates in patients with Li-Fraumeni syndrome
Trial participants express willingness for personalized genetic counseling over standard methods in Li-Fraumeni Syndrome, suggesting implications for future research.
Key Points
The aim is to assess patient willingness to participate in a trial comparing standard genetic counseling to personalized genetic counseling based on a new risk model.
Targeted individuals aged 15 and older who underwent genetic counseling for TP53 testing
Distributed a questionnaire via secure email to gather clinical characteristics and participation interest
Compared standard genetic counseling with personalized approaches informed by LFSPRO data
Questionnaire return rate was 17.9% (65 out of 364 invited)
81.5% of respondents expressed strong interest in participating in the trial
76.9% preferred personalized genetic counseling over standard methods
66.2% felt comfortable with random assignment in the trial