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March 1, 2026British Journal of Dermatology0 citationsOpen Access

Comparative performance of four immunoassays for anti-laminin 332 serum IgG in mucous membrane pemphigoid: a multicentre prospective blinded study

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SGS. Goletz石文石井 文人CKCharlotte Kiehne

Key Points

  • This study aims to compare the effectiveness of four immunoassays for detecting anti-laminin 332 IgG in mucous membrane pemphigoid.
  • Multicentre study design
  • Use of four different immunoassays
  • Blinded comparison of assay performance
  • Assessment of diagnostic accuracy and specificity
  • The keratinocyte footprint assay demonstrated the highest diagnostic accuracy among the assays tested.
  • The laminin 332 Biochip® exhibited excellent specificity for diagnosis.
  • Differences in performance metrics suggest varying utility of assays in clinical practice.

Abstract

This multicentre study compares four immunoassays for detecting anti-laminin 332 IgG in mucous membrane pemphigoid. The keratinocyte footprint assay showed the highest diagnostic accuracy, while the laminin 332 Biochip® provided excellent specificity as a standardized and widely accessible diagnostic option.

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Cite This Study

Goletz et al. (2026) studied this question.

synapsesocial.com/papers/69a3d8caec16d51705d2ff6ehttps://doi.org/10.1093/bjd/ljag065
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