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March 3, 2026Cancers0 citationsOpen Access

Tumor-Associated Neutrophils and Desmoplastic Reaction in Breast Cancer Microenvironment: Association with Tumor Grade and Clinicopathological Features

SPStavroula PapadopoulouVMVasiliki MichouATArsenios Tsiotsias

Key Points

  • High levels of tumor-associated neutrophils are primarily associated with aggressive tumor grades.
  • Myxoid stroma may serve as a significant indicator of a highly aggressive tumor microenvironment.
  • The findings suggest a need for further validation in larger, prospective studies for robust conclusions.
  • This preliminary association highlights the importance of understanding clinicopathological features in breast cancer.

Abstract

High TAN levels were linked to aggressive tumor features and specific DR patterns. The association of myxoid stroma with elevated TAN infiltration may reflect a highly aggressive TME. These preliminary results warrant validation in larger, prospective studies.

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Cite This Study

Papadopoulou et al. (2026) studied this question.

synapsesocial.com/papers/69a75a6dc6e9836116a20342https://doi.org/10.3390/cancers18030406
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