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March 3, 2026Microorganisms0 citationsOpen Access

Anti-Coxsackievirus B4 Activity in Mice Exposed via Mucosal Route

Anti-Coxsackievirus B4 Activity of Serum and Saliva from Mice Exposed to the Virus via the Mucosal Route

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Population

Swiss albino mice

Design

Preclinical

Follow-up

45 days

Authors

CMChaldam Jespère MbaniMNMagloire Pandoua NekouaLCLaurine Couture

Discussion

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Overview

Should not yet change practice for CVB-linked cardiomyopathy; extends intraperitoneal models as a platform for protective mucosal immunity research.

Key Points

  • Anti-CVB4 neutralizing activity was detected in serum and saliva of mice, suggesting effective humoral immune response.
  • At day 45 post-inoculation, both serum and saliva showed increased anti-CVB4 neutralizing activity after mucosal exposure.
  • Assessment utilized cell culture neutralization and RT-qPCR to evaluate immunity after mucosal inoculation.
  • Indications from serum enhancement activity point to a novel approach for exploring mucosal and systemic immunity.

Structured PICO

P
Population
Swiss albino mice
I
Intervention
Oral or intranasal inoculation with Coxsackievirus B4 (CVB4)
O
Outcome
Anti-CVB4 neutralizing activity of serum and saliva, anti-enterovirus IgG and IgA antibodies, and serum-dependent enhancement of CVB4 infectionsurrogate

Mucosal exposure to CVB4 in Swiss albino mice induces both neutralizing and enhancing antibodies, providing a model to test strategies for promoting protective mucosal immunity.

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Cite This Study

Mbani et al. (2026) studied this question.

synapsesocial.com/papers/69a75a9dc6e9836116a20acchttps://doi.org/10.3390/microorganisms14020289
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