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March 3, 2026Microcirculation1 citations

An Animal Model of Coronary Microvascular Dysfunction ( CMD ) in the Female Spontaneously Hypertensive Rat: The Role of Diet

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RNRami S. NajjarPMPuja K. MehtaAGAndrew T. Gewirtz

Key Points

  • Coronary microvascular dysfunction develops in response to dietary changes, indicating a strong link to hypertension.
  • The study highlights the role of diet as a crucial factor influencing CMD in female spontaneously hypertensive rats.
  • Animal model experiments show how dietary interventions may affect coronary microvascular health and hypertension dynamics.
  • Understanding CMD in this model paves the way for better therapies targeting hypertension-related microvascular issues.

Abstract

SHRs develop a diet-dependent CMD, which can serve as a model to study hypertension-related CMD.

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Cite This Study

Najjar et al. (2026) studied this question.

synapsesocial.com/papers/69a75a9ec6e9836116a20ae7https://doi.org/10.1111/micc.70052
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