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March 3, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Assessing cortical bone changes with Romosozumab after one year: Insights from an exploratory HR-pQCT study

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MZMaría Belén ZanchettaMPMariana Gonzalez PernasFJFernando Jerkovich

Key Points

  • Rapid cortical bone improvements were detected in 56% of treatment responders at 6 months, indicating effective intervention.
  • Cortical bone changes were assessed using high-resolution peripheral quantitative computed tomography (HR-pQCT).
  • Patients were stratified based on changes in cortical thickness (Ct.Th) to identify those responsive to Romosozumab treatment.
  • Future investigations are needed to explore clinical predictors of responsiveness and potential adjustments to treatment duration.

Abstract

By stratifying patients based on Ct.Th changes, we identified treatment responders (56%) with rapid cortical bone improvements detectable at 6 monthsIdentifying clinical predictors of ROMO responsiveness and determining whether shorter treatment durations may be justified in selected patients warrant further investigation.

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Cite This Study

Zanchetta et al. (2026) studied this question.

synapsesocial.com/papers/69a75a9ec6e9836116a20afbhttps://doi.org/10.1016/j.bonr.2026.101902
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